What the hell! C# question

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IronPython is the .Net implementation of Python. (JIT via .Net CLR compiler)
http://www.codeplex.com/Wiki/View.aspx?ProjectName=IronPython


Jython is another similar product (JIT via java byte code compiler)
http://www.jython.org/Project/


If you want improved performance in standard python, you could use Psyco. (Though beware that you have to adopt some pretty strict coding standards to gain benefit from it)
http://psyco.sourceforge.net/