Spore will have more unique content than any other retail game before it and for that all it needs is a connection to the internet. Forget physical media, the future of game content is streaming.
Gosh. I hope not.
Inevitably, programs fall into a category of unsupported. If you give the publisher all of the control over when you can access media to a game, you're pretty much establishing a pretty short life for it. If the publisher sees that only 5% of the time is spent playing game X, and they need it played at least 6% to justify it's existence on their servers, it will most assuredly be on the chopping block.
And heaven forbid that a publisher releases a couple of rotten games and goes out of business (which will be more likely to happen when the expectations and risk management associated with next generation games is nightmarish). Where will the content come from then?
If that's the future, then it's a bleak one.