And yes. Mario looks like ron jeremy. That tickles me endlessly.
Back in my video retail days, I worked in a video store that had a "back room" with movies that starred the likes of Ron Jeremy.
I seem to recall a pr0n parody that came out around the time that the Super Mario Bros. movie came out, and he was in it.
Dampe... It's a cool site, however, I kinda get the vibe that you're trying to be an "edgy version of Penny Arcade".
That's fine, but when you start putting adult situations and "offensive" material in it, you're going to lose the office cubical crowd that has made Penny Arcade a success. (In other words, I couldn't in all confidence read your comic at work with fear of who might be reading it over my shoulder and take offense to it)
Heck.. I have elementary school-aged children, so I have to be careful if I were to look at it at home as well.
Here's a suggestion if you're looking for feedback:
Perhaps a good compromise would be to do the pixelated blurry censoring region if you have to portray nudity. Since it's pixelated, you might even be able to work that into the joke somehow...