XNA is tempting, but the thing that really prevents me from using it is that it will go through major (and I mean MAJOR) revisions every year or so, whereas OpenGL uses the same API it did ten years ago (even while adding support for all the features of DX10). I think using an MS development system would create a huge programming hours increase. If you're the head of a company that already employs 50 programmers, this isn't such a big deal, but it can kill a small developer.
Looking at XNA
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