If you are doing anything with a gui, its hard to beat c# and vb.net. However, the built in System.Drawing classes(gdi+) for .net are very slow, and imo a pain in the ass to use.
You can get by with them, but I'd recommend using the various tao framework bindings like sdl and opengl, or managed directx/xna.
You can get by with them, but I'd recommend using the various tao framework bindings like sdl and opengl, or managed directx/xna.