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Genetic Engeneering isn't 'applied evolution' it isn't small changes over long periods.

People forget. genetic mutation was un-known or little-known to darwin. The thoery of evolution doesn't really account for mutation, it is based on the idea that the parent's genes are the cause of change, and in most cases it is.

Mutation accounts for the some of the great leaps. Such as Spines, and brains, and new limbs or lost limbs. Mutation is common, but in order for it to be passed on, the mutation must take place in a sex-cell, like an egg or sperm, or in a cell that produces those cells. Then that mutation has to be a good one, rather than a mutation that causes a defect that isn't useful. Or at least not a deficit. Scorpions for example. They used to have secondary claws, but those claws went away. Either over time, or in a mutation. Negative mutations that don't cause death can still be passed on, provided they are dominant.

Applied Evolution is impossible... With the possible exception of weaponized microbes, which are exposed to large numbers of toxins to bread microbes that withstand all the toxins.

However, it still doesn't apply to mutations.