RAID 0 and 1 combined?

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RAID 0+1 = Less fault tolerance
RAID 1+0 = Better fault tolerance
RAID 5 = Is better than the previous two but a small decrease in speed due to parity. However if you have good RAID hardware and can cache reads/writes then the speed difference is reduced even further.

If you want raw speed with average fault tolerance then go for RAID 1+0, else go for RAID 5 if you don't mind losing a little speed under certain circustances.

However you cut it, any of those will increase performance over a single drive solution.

If I were doing it for personal use then I'd go for RAID 1+0 and still backup important data (always). If I were doing it for a company then I'd go for maximum reliability.