SUSE on a USB hard drive?

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I know most Linux distro's have to be heavily tweaked to get them working off a USB hard drive, so I'm wondering if any SUSE users can tell me whether this is also the case with SUSE or if the latest version would work ok? Since I bought a new 300 gig hard drive, I have a spare 120gig drive I could format and install linux on, and I hear good things about the new build of SUSE. But I don't want boot loaders and all that crap clogging up my main internal drive. I want to set the bios to boot from USB and install on that only. If it's not possible to do as I've outlined, I just won't bother.