I think he means, say every tile is 32x32 then everything in the game is spaced like that so it's really obvious. In fact Tomb Raider was like this! Just in 3D. I made a platformer (Iron Fist - unfinshed), checkout http://www.greyaliengames.com . One thing I made sure was I didn't use "tiles", I used "objects" that can be positioned anywhere meaning interesting levels could be designed, although in reality you still end up using standard spacing a lot, but it's good for rubble and stuff like that.