Might be close to what you want...
Graphics 640,480
image:TImage=LoadImage("max.png")
While Not KeyHit(KEY_ESCAPE)
Cls
DrawImage image,0,0
If MouseDown(1)
SetBlend lightblend
SetAlpha 0.6
DrawRect 0,0,640,480
SetBlend maskblend
SetAlpha 1.0
EndIf
Flip
Wend