What, even if it makes them hate your guts and vow to never buy one of your products again? Games, if they're any good, are played for hours... the potential for the player to become sick of the sight of any in-game advertised produce is vast.
Allow me to repeat: "take advantage of the game 'Down-Times': TitleScreens, Loading, Pause, Game Over" If this is a concern the Developer could provide the option to turn them off or provide and incentive for viewing them. There is more than one way to skin a ...