I'm noticing jerkiness every now and again in my game
It is most probably a windows background task causing momentary latency. To confirm this call up task manager and close all non-essential tasks.
If this resolves the problem for you, then many of your target users may experience the same problem.
I'm not personally experienced with frame tweening, I use delta timing myself and so I solve this by averaging the delta from the last 5 frames which gives a kind of suspension effect and helps to trick the eye into not noticeing momentary pauses.