What are the causes of lockups with Debug on

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What are the causes of system instability with Debug Turned on?
I'm developing on a Win2000 box.
I have 2 cameras.

When I try to run my code with Debug turned on I get what looks like a too fast refresh rate problem on my scren. Horozontol multicolored thin lines, Esc will not allow me out of the program. It runs fine with Debug turned off.