Animated Textures - Power of 2 in size?

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Good Afternoon (well it's afternoon here anyway),

Given textures should usually be powers of 2 in both width and height dimensions what is the case with animated textures. Is it the individual frames that should be a power of 2 or the original texture that the frames are taken from, or should it be both?

For example if I have an animated texture with 3 frames each of 64 x 64 pixels, should the complete texture be
128x128 containing 4 frames - one of them blank.

Or is it okay to have a texture which is 192x64 in size containing 3 64x64 frames?

On my PC I've never had problems with odd sized textures but I'd rather not risk it with other people's machines.